Yang Sun

This study characterizes 4-methyl-3-aminopyridine as a potent KV channel blocker with improved pharmacological properties compared to 4-aminopyridine.

This study introduces a PET tracer, [18F]3F4AP, to image demyelinated axons in spinal cord injuries and shows its ability to detect injury and monitor changes in animal models and humans.

This paper synthesizes [18F]5Me3F4AP, a K+ channel PET radioligand, and demonstrates its brain uptake and kinetics in mice, suggesting it as a potential improved tracer for demyelination imaging.

This study shows that isoflurane anesthesia inhibits [18F]3F4AP metabolism in mice, leading to higher brain uptake, similar to human studies, and highlights the need to consider anesthesia effects in PET tracer translation.

This study evaluates two fluorinated gabapentin derivatives for brain PET imaging of 2{delta} receptors in rhesus macaques, showing differential brain uptake and displacement characteristics.

This paper characterizes 5Me3F4AP, a novel K+ channel blocker with improved physicochemical properties and stability compared to existing PET tracers for demyelinated lesion imaging.

The paper describes the synthesis and evaluation of [11C]3Me4AP, a tracer for imaging Kv1 channels in the CNS, showing lower brain uptake and slower kinetics compared to related tracers.

This paper develops two 18F-labeled gabapentin derivatives for imaging the α2δ-1 subunit of calcium channels in neuropathic pain, showing increased uptake in injured nerves.