Akihito Harada

The paper shows SOX2 terminates trophectoderm competence in inner cell mass by closing Hippo signaling-responsive enhancers through chromatin closure.

This study identifies AR-dependent Mybph repression as a mechanism contributing to skeletal muscle sexual dimorphism using ChIL-seq and an AirID-AR knock-in mouse.

The paper shows that chromatin modifications around genes fluctuate with transcriptional activity in mouse embryonic stem cells, revealing minute-scale coupling between histone marks and transcriptional bursts.

The paper uses time-course RNA-seq to study muscle remodeling in Drosophila, identifying BNIP3-mediated mitophagy as critical for mitochondrial degradation during this process.

The paper investigates the role of H2bc27, an H2B isoform, in mouse brain development through gene expression analysis and knockout studies, finding it regulates gene expression in brain development.

This study shows that trifluridine induces aberrant mitosis and cytotoxicity in both p53-null and p53-GOF mutant cells, independent of p53 function.

The paper introduces PECAbs for high-specificity multiplexed imaging of cell states and combines them with seq-smFISH to classify cells and identify signal activation states in human tissue.

The paper identifies genes and genomic regions responsible for PPIX production in the uterus of Japanese quail, linking them to eggshell pigmentation.

The paper introduces tsChIL, a method to analyze tissue-level epigenomic data from single-thin sections, enabling independent evaluation of cell population changes and gene activation in regenerating skeletal muscle.

This paper introduces PIC, a method for high-resolution spatial transcriptome analysis, and shows it detects gene expression in small regions of mouse embryos.

This study investigates transcriptional bursting kinetics in mESCs using scRNA-seq and identifies regulatory factors and pathways influencing gene expression noise.