Michel Haı̈ssaguerre

This study investigates the pathogenic effects of the DES p.R406W mutation, showing it causes electrical and structural heart remodeling linked to arrhythmias and sudden cardiac death.

This paper develops a deep learning-based method to isolate and classify Purkinje fiber cells from adult sheep hearts using imaging data and validation techniques.

This study shows that increased spontaneous Ca2+ activity in cardiac Purkinje cells after myocardial infarction is due to a shift in SERCA2 isoforms, specifically increased SERCA2b and reduced SERCA2a.