Michael Bscheider

This study develops human intestinal immuno-organoids (IIOs) that integrate tissue-resident immune cells, enabling the study of intestinal inflammation and immune responses in disease contexts.

The paper develops a Lymphoid Organ-Chip to evaluate mRNA vaccine boosting strategies by mimicking immune responses to SARS-CoV-2 Spike protein and comparing monovalent and bivalent vaccines.

This paper develops bioengineered human colon organoids that mimic in vivo complexity and function, enabling long-term study of gut physiology and disease.

The paper introduces tSpace, a computational method for analyzing developmental pathways in single-cell data, and shows it reconstructs known developmental sequences and reveals new insights into B cell development and intestinal epithelial differentiation.