Xueliang Zhu

This study reveals the subnanometer architecture of basal bodies in mammalian cells, identifies new components, and proposes a mechanism for central pair microtubule nucleation during ciliogenesis.

The paper identifies the proteomic composition and functional interdependence of the vertebrate C2a projection, showing that loss of any of three proteins causes ciliary dysfunction and primary ciliary dyskinesia in mice.

The paper identifies TRiC/CCT as a chaperonin in mammalian sperm flagella that folds locally translated proteins, supporting flagellar function and fertility.

This study shows that Spef1 undergoes liquid-liquid phase separation to facilitate non-centrosomal microtubule assembly by enriching tubulins, with its coiled-coil domain mediating this process.

This study identifies CCP5's N-domain as critical for ependymal multicilia stability, polarization, and coordination, preventing hydrocephalus in mice.

This study identifies distinct roles of Kif6 and Kif9 in mammalian ciliary trafficking and motility, showing Kif6 is a motile cilia-specific IFT motor while Kif9 regulates the central apparatus.

This study identifies lysine succinylation changes in Vero cells infected with SRMV, revealing 2633 sites and highlighting their role in cellular respiration and metabolism.