Samuel H. Grindel

This paper uses optogenetic control of RET signaling to induce controlled budding in human kidney organoids.

The paper maps human kidney development using single-cell RNA sequencing and spatial transcriptomics, revealing fate decisions influenced by the local microenvironment.

This paper develops a method to produce designer organoids with controlled progenitor ratios and morphology using DNA velcro cell patterning.

This study identifies a mechanical pacemaker in the kidney stroma that synchronizes nephron formation with ureteric bud branching.

This study shows that Rho/ROCK inhibition enhances mixing between nephron progenitor and stromal cells, increasing nephrogenesis in kidney organoids.