Aria Zheyuan Huang

This paper uses optogenetic control of RET signaling to induce controlled budding in human kidney organoids.

This paper develops a 3D culture technique to study kidney development and shows that matrix stiffness and adhesion influence nephron formation and spacing.

The paper maps human kidney development using single-cell RNA sequencing and spatial transcriptomics, revealing fate decisions influenced by the local microenvironment.

MATCHY quantifies cell adhesion and traction in primary kidney cells, revealing an energetic ratchet mechanism driving nephron condensation during differentiation.

This study shows that Rho/ROCK inhibition enhances mixing between nephron progenitor and stromal cells, increasing nephrogenesis in kidney organoids.