Onno Kranenburg

The paper identifies location-specific transcriptional differences in tumor-infiltrating Treg cells across CRC metastases and links these to poor patient prognosis.

This study shows that mechanical signals from the Collagen I-rich matrix drive fate transitions in colorectal cancer cells, enabling metastasis despite lacking Lgr5 expression.

This study shows that combining ATR inhibitors with mitomycin C significantly reduces viability of NMIBC organoids compared to chemotherapy or ATR inhibitors alone.

The paper develops a γδT-omics pipeline to analyze compartmentalization of Vδ1⁺ T cell migration, tumor-reactivity, and clonality in human colorectal cancer, revealing distinct functional and transcriptional features across tumor compartments.

This study shows that nanofibrillar cellulose hydrogels preserve T cell function better than Matrigel or basement membrane extract in 3D cultures.

This study shows CRC tumor organoids induce Treg cells via TGFβ-dependent differentiation, with distinct transcriptional profiles and prognostic relevance in CRC patients.

This study examines the evolutionary dynamics of peritoneal metastases in colorectal cancer, finding they are more heterogeneous than liver metastases but less diverse than locoregional metastases.

This study shows that pre-existing subclones in rectal cancer organoids determine radioresistance, with resistance linked to reduced chromosomal instability.

The paper identifies stromal localization of inactive CD8+ T cells in metastatic MSI-H CRC and links it to poor immune response.