Michael M. Gottesman

The paper uses intravital imaging in zebrafish to show age-dependent changes in collective T cell migration patterns in fins, linking tissue structure and immune function.

The paper identifies SLC43A1 (LAT3) as a key determinant of oxaliplatin sensitivity in colorectal cancer cells through CRISPR screens and functional validation.

This study identifies early transcriptional signatures of drug resistance in cancer and across species, showing conservation and predictive value for treatment response.

The paper investigates how Angubindin-1 disrupts the blood-tumor barrier by targeting Angulin-1/LSR, enhancing drug permeability and reducing glioma progression.

This paper identifies DLK1 as a novel immunotherapeutic target in adrenocortical carcinoma, showing it regulates tumor cell plasticity and chemoresistance, and demonstrates the efficacy of a DLK1-targeting antibody-drug conjugate.

This study identifies ADC payloads transported by ABC transporters, showing potential for drug resistance and suggesting payload selection to avoid this.

The paper identifies NanoLuciferase substrates transported by human and zebrafish ABC transporters at the BBB, aiding in the development of a transgenic zebrafish model to detect BBB disruptors.

This study shows that TMT1A's ability to methylate thiol-based HDAC inhibitors is conserved across species, suggesting its functional relevance in animal models.

The paper compares cancer cell growth and gene expression in different oxygen environments, finding that controlled oxygen delivery in 3D cultures better mimics physiological conditions.