Jose Renato Pinto

This study reports the high-resolution structure of the native cardiac rigor cross-bridge, revealing how myosin heads and thin filament components coordinate during contraction.

The paper compares myosin filament structures across vertebrate skeletal and cardiac muscle, finding high similarity but differences in myosin binding protein C positioning.

This study shows that DSG2 deficiency causes cardiac dysfunction by impairing Z-disc and intercalated disc mechanotransduction, leading to structural and functional cardiac defects.

This study identifies sMyBP-C's critical role in skeletal muscle development and function using gene-edited mouse models, showing its necessity for prenatal and postnatal muscle growth and structural integrity.