Celestine N. Wanjalla

The paper classifies human Th17 cells into non-pathogenic and pathogenic states and identifies acylcarnitine metabolism as a vulnerability in type 2 diabetes.

This study shows ATF4 coordinates transcriptomic and structural changes in aging muscle, linking it to mitochondrial dysfunction and suggesting the ISR pathway as a therapeutic target.

The paper uses mass cytometry to analyze monocyte subtypes in a Ugandan cohort with HIV, TB, and CAD, identifying distinct phenotypes linked to disease states.

The paper shows that intermicrovillar adhesion complexes limit bacterial attachment to the small intestine brush border, with SFB remodeling actin to anchor to epithelial junctions.

The paper uses multiomic single-cell sequencing to analyze SJS/TEN patients' skin and blister fluid, identifying tissue-specific immune responses and T-cell clonotypes involved in pathogenesis.

This study examines cytokine and chemokine receptor expression in adipose tissue endothelial cells of HIV-positive individuals, identifying receptor differences and their potential role in vascular dysfunction.

This study identifies glucocorticoid receptor (GR) signaling in myeloid cells as a key contributor to salt-sensitive hypertension (SSBP) through SGK1 and IsoLG pathways, distinct from mineralocorticoid receptor (MR) mechanisms.

The paper identifies monocyte-endothelial interaction alterations in TET2 CHIP and shows that targeting CXCR2 and ICAM1 can restore normal interactions.

This study identifies structural and metabolic changes in human heart failure using SBF-SEM and metabolomic analyses.