Annet Kirabo

This study identifies ATF4 as a master regulator of mitochondrial structural plasticity through a novel signaling axis, showing its role in stress-induced mitochondrial remodeling.

This study investigates age-related mitochondrial structural deficits in the kidney, finding that the MICOS complex is impaired, leading to increased oxidative stress and mitochondrial dysfunction.

This study uses 3D electron microscopy to analyze mitochondrial network changes in residual triple negative breast cancer after chemotherapy, revealing structural remodeling and lipid droplet interactions associated with chemoresistance.

This study investigates how MICOS disruption affects mitochondrial structure and function in neurons vulnerable to Alzheimer's disease, linking these changes to early mitochondrial dysfunction and neuronal vulnerability.

This study shows ATF4 coordinates transcriptomic and structural changes in aging muscle, linking it to mitochondrial dysfunction and suggesting the ISR pathway as a therapeutic target.

This study investigates age-related changes in mitochondrial 3D structure in human skeletal muscle and shows that exercise can restore mitochondrial integrity through mitofusin 2.

This study investigates age-related changes in mitochondrial structure and function in the liver, identifying MICOS complex dysregulation as a contributor to metabolic and structural impairments.

This study identifies glucocorticoid receptor (GR) signaling in myeloid cells as a key contributor to salt-sensitive hypertension (SSBP) through SGK1 and IsoLG pathways, distinct from mineralocorticoid receptor (MR) mechanisms.

This study investigates the association between JAK-STAT pathway gene expression and hypertension in Kenyan women with breast cancer, finding significant correlations between specific genes and blood pressure metrics.

This study investigates the impact of proteolytic cleavage of the ENaC gamma subunit on Na+ and K+ handling in mice, finding that cleavage is not essential for channel activity in vivo.

This paper provides validated dietary strategies to modulate zinc homeostasis in mice and outlines methods to assess zinc status, enhancing reproducibility in disease-related studies.

This study identifies structural and metabolic changes in human heart failure using SBF-SEM and metabolomic analyses.