Bret C. Mobley

The paper investigates Serpin A3 expression in cerebral amyloid angiopathy and Alzheimer's disease using single-nucleus transcriptomics and microscopy, finding increased Serpin A3 in affected tissues.

This study investigates age-related mitochondrial structural deficits in the kidney, finding that the MICOS complex is impaired, leading to increased oxidative stress and mitochondrial dysfunction.

This study investigates how MICOS disruption affects mitochondrial structure and function in neurons vulnerable to Alzheimer's disease, linking these changes to early mitochondrial dysfunction and neuronal vulnerability.

This study shows ATF4 coordinates transcriptomic and structural changes in aging muscle, linking it to mitochondrial dysfunction and suggesting the ISR pathway as a therapeutic target.

This study investigates age-related changes in mitochondrial 3D structure in human skeletal muscle and shows that exercise can restore mitochondrial integrity through mitofusin 2.

This study shows PLD3 regulates lysosomal morphology, biogenesis, and function in neurons by affecting protein abundance, subcellular location, and clearance of aggregated proteins.

The paper develops a machine learning tool to identify balloon cells in TSC brain tissues using imaging mass cytometry and a custom antibody panel.

This study investigates age-related changes in mitochondrial structure and function in the liver, identifying MICOS complex dysregulation as a contributor to metabolic and structural impairments.

This study identifies IL-8 as a key factor instructing macrophage identity in glioblastoma, showing IL-8 is necessary for generating CD32+ M_IL-8 macrophages in tumors contacting the lateral ventricle.

This study links β-amyloid deposition and lysyl oxidase to arteriolar degeneration and stiffness in cerebral amyloid angiopathy using post-mortem human brain tissue analysis.

This study identifies structural and metabolic changes in human heart failure using SBF-SEM and metabolomic analyses.