Human Heart Failure Alters Mitochondria and Fiber 3D Structure Triggering Metabolic Shifts
Z. Vue, P. T. Ajayi, K. Neikirk, A. Murphy, P. Prasad, B. C. Jenkins, L. Vang, E. Garza-Lopez, M. Mungai, A. G. Marshall, H. K. Beasley, M. Killion, R. Parker, J. Anukodem, K. Lavine, O. Ajijola, B. Mobley, D.-F. Dai, V. Exil, A. Kirabo, Y. Ru Su, K. Tomasek, X. Zhang, C. N. Wanjalla, D. L. Hubert, , A. Hinton
Abstract
This study, utilizing SBF-SEM, reveals structural alterations in mitochondria and myofibrils in human heart failure (HF). Mitochondria in HF show changes in structure, while myofibrils exhibit increased cross-sectional area and branching. Metabolomic and lipidomic analyses indicate concomitant dysregulation in key pathways. The findings underscore the need for personalized treatments considering individualized structural changes in HF.
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