Antentor Othrell Hinton Jr.

This study shows that Annexin A6 promotes secretion of pro-inflammatory cytokines and exosomes in TNBC cells through interaction with SNAP23.

This study identifies ATF4 as a master regulator of mitochondrial structural plasticity through a novel signaling axis, showing its role in stress-induced mitochondrial remodeling.

This study investigates age-related mitochondrial structural deficits in the kidney, finding that the MICOS complex is impaired, leading to increased oxidative stress and mitochondrial dysfunction.

This study uses 3D electron microscopy to analyze mitochondrial network changes in residual triple negative breast cancer after chemotherapy, revealing structural remodeling and lipid droplet interactions associated with chemoresistance.

This study identifies DNA damage-driven senescence and ZBP1-cGAS-STING signaling as conserved mechanisms linking cardiovascular-kidney-metabolic comorbidities to HFpEF.

This study investigates how MICOS disruption affects mitochondrial structure and function in neurons vulnerable to Alzheimer's disease, linking these changes to early mitochondrial dysfunction and neuronal vulnerability.

This study shows ATF4 coordinates transcriptomic and structural changes in aging muscle, linking it to mitochondrial dysfunction and suggesting the ISR pathway as a therapeutic target.

This study shows Derlin-mediated ERAD of ORMDL3 prevents mitochondrial dysfunction by maintaining sphingolipid homeostasis and ER-mitochondria contact sites.

This paper provides a comprehensive protocol for quantifying cellular organelles using light microscopy and Fiji/ImageJ, enabling precise, high-throughput, and statistically comparable measurements across different samples.

This study shows that mitotic nanotubes, influenced by Cx43 trafficking and actin remodeling, enable reduced gap junction communication during cell division.

This study uses a zebrafish model of cblX syndrome to show that mTor inhibition at moderate doses reduces seizure severity, but higher doses cause a refractory response in hcfc1a mutants.

This study shows that the lysosomal LRRC8 complex regulates lysosomal pH, morphology, and systemic glucose metabolism by affecting mTOR signaling and autophagic flux.

This study uses metabolomic profiling in Drosophila melanogaster to show that selection for early reproduction leads to repeatable metabolic changes and a reliable predictor of biological age.

This study investigates age-related changes in mitochondrial 3D structure in human skeletal muscle and shows that exercise can restore mitochondrial integrity through mitofusin 2.

The paper introduces an AI model to analyze mitochondrial morphology in TNBC using TEM images, finding significant structural changes in response to chemotherapy and metastasis.

This study examines changes in myofibril size, shape, and connectivity in aging muscle across mice and humans, finding increased connectivity and variable size/shape changes depending on muscle type.

This study examines cytokine and chemokine receptor expression in adipose tissue endothelial cells of HIV-positive individuals, identifying receptor differences and their potential role in vascular dysfunction.

This study shows MIRO1 regulates VSMC proliferation and neointima formation by controlling mitochondrial positioning, ATP production, and ETC function.

This study investigates age-related changes in mitochondrial structure and function in the liver, identifying MICOS complex dysregulation as a contributor to metabolic and structural impairments.

This study identifies glucocorticoid receptor (GR) signaling in myeloid cells as a key contributor to salt-sensitive hypertension (SSBP) through SGK1 and IsoLG pathways, distinct from mineralocorticoid receptor (MR) mechanisms.

This paper provides validated dietary strategies to modulate zinc homeostasis in mice and outlines methods to assess zinc status, enhancing reproducibility in disease-related studies.

This study identifies structural and metabolic changes in human heart failure using SBF-SEM and metabolomic analyses.