Andrew Santiago‐Frangos

This study identifies Tiamat as an ATPase and DNase in bacteria and shows its homologs are widespread across eukaryotes, with some acquiring non-defense roles.

The paper shows that adaptive protein coevolution within a telomere protection complex preserves telomere integrity by mitigating interspecies incompatibility caused by rapid evolution.

The paper determines structures of the Cas1-2/3 complex to elucidate how it captures, delivers, and integrates foreign DNA into CRISPR loci.

The paper shows that viral proteins activate PARIS-mediated tRNA degradation, and viral tRNAs rescue infection by preventing cleavage.

This study characterizes the bacteriophage phiBB-1 using proteomics and long-read sequencing, revealing its packaging mechanisms and role in gene transfer in Borrelia burgdorferi.

The paper presents the cryo-EM structure of the type I-F CRISPR surveillance complex and shows a conformational change that exposes a nuclease recruitment helix homologous to an anti-CRISPR protein.