Kaixian Liu

The paper analyzes evolutionary divergence in meiotic recombination proteins across four taxa, identifying regions under positive selection and functional constraints using structural and functional data.

This study reconstitutes SPO11-dependent DNA double-strand break formation in vitro, revealing dimerization-dependent cleavage and topoisomerase activity.

The paper reports cryo-EM structures of Spo11 core complexes bound to DNA, revealing DNA-binding specificity and structural variation in homologs.