Juncheng Wang

The paper reports cryo-EM structures of Spo11 core complexes bound to DNA, revealing DNA-binding specificity and structural variation in homologs.

The paper reveals the structural mechanism of ATP-dependent DNA methylation by DNMT5, showing how hemimethylated DNA activates the SNF2 ATPase domain and remodels the catalytic pocket for specificity.

The paper reveals how the piRNA pathway connects to the heterochromatin machinery in Drosophila through SUMOylation of Panoramix and its interaction with Sov.

This study identifies the role of the SFiNX complex dimerization in enabling co-transcriptional silencing via molecular condensate formation in Drosophila.

This study investigates how DNA-dependent macromolecular condensation facilitates the self-assembly of the meiotic DNA break machinery in yeast.

This study identifies SFiNX, a complex required for Piwi-mediated co-transcriptional silencing in Drosophila, revealing its role in piRNA-guided heterochromatin formation.

This study identifies ANKRD31 as a regulator of meiotic DNA break formation in mice, showing its role in controlling DSB number, timing, and location, and linking its dysfunction to infertility.