Simon Poepsel

This study compares the demethylase activity, nucleosome engagement, and RB binding of KDM5A and KDM5B, revealing differences in their interactions and enzymatic behavior.

This study identifies FAM136A as a mitochondrial disulphide relay substrate essential for IMS proteostasis, showing its role in cellular fitness and stress response.

This study identifies the molecular mechanism of gephyrin clustering at GABAergic synapses, showing collybistin and phosphoinositides drive high-molecular weight complex formation, while gephyrin phosphorylation at Ser325 disrupts it.

This study characterizes the conformational changes of the BiP-GRP94 chaperone complex and identifies the structural basis of their interaction without co-chaperones.

The paper identifies AIFM1's interaction with AK2A and shows how this stabilizes AK2A and enhances NADH oxidoreductase activity, highlighting AIFM1's role in energy metabolism.

This study identifies KDM5B's role in regulating the PRDX/TXN ROS detoxification system in melanoma DTPs, showing that PRDX inhibition increases ROS vulnerability and delays resistance to MAPK inhibition.

This study identifies HTRA1 as a non-autonomous protein quality control factor that inhibits tau aggregate propagation by interfering with multiple steps of the spreading process.

This study shows MPO enters endothelial cell nuclei, binds chromatin non-enzymatically, and regulates EndMT and EC fate through chromatin remodeling and interaction with ILF3.

The paper uses cryo-EM to determine the atomic structure of tau-tubulin interactions, revealing how tau stabilizes microtubules through specific binding sites.