Shuo Tian

SheepEpimap combines 516 histone CUT&Tag, ATAC-seq and RNA-seq datasets from 43 sheep tissues to annotate 2.93 million cis-regulatory elements and 145,407 allele-specific variants for trait interpretation.

This study identifies a phosphorylation code in 14-3-3 binding motifs that stimulates induced cardiomyocyte formation by disrupting Hdac4 condensates.

This study identifies BRD4 degradation as a method to enhance cardiac reprogramming by inhibiting the JAK/STAT pathway activated by macrophages and oncostatin M.

This study shows BAF250a facilitates cardiac differentiation by enabling OCT4 and β-catenin interaction, affecting gene expression and cell cycle progression in human ESCs.

The paper identifies a chemical combination (IMAP) that enhances cardiac reprogramming by suppressing specific C-C chemokine signaling pathways.