Ienglam Lei

This study shows preoperative MRA use reduces new-onset POAF and long-standing AF development, with canrenone suppressing MR target genes linked to chronic AF in atrial cardiomyocytes during cold preservation.

This study uses quantitative proteomics to identify ECM protein alterations in end-stage ICM, revealing key upregulated components and pathways involved in adverse remodeling.

This study identifies BRD4 degradation as a method to enhance cardiac reprogramming by inhibiting the JAK/STAT pathway activated by macrophages and oncostatin M.

This study shows BAF250a facilitates cardiac differentiation by enabling OCT4 and β-catenin interaction, affecting gene expression and cell cycle progression in human ESCs.

The paper identifies a chemical combination (IMAP) that enhances cardiac reprogramming by suppressing specific C-C chemokine signaling pathways.