Santi M. Mandal

This paper identifies the PFKFB3-F2,6BP metabolic axis as a key driver of Alzheimer's disease by linking metabolic dysregulation to genomic stability and Tau proteostasis, showing that F2,6BP supplementation rescues AD phenotypes across multiple models.

This study shows that fructose-2,6-bisphosphate (F2,6BP) restores genome repair and motor function in TDP-43 pathology-driven motor neuron diseases.

This paper shows that F2,6BP restores mitochondrial genome integrity in Huntington's Disease by rescuing PNKP activity and mitochondrial function.

This study shows that F2,6BP restores PNKP activity and alleviates neurodegenerative symptoms in HD and SCA3 by rescuing DNA repair and genome integrity.

This paper evaluates a polyherbal formulation AP-01 for treating ricinoleic acid-induced diarrhea in rats and demonstrates its in vitro antibacterial activity against antibiotic-resistant gastric pathogens.