BiochemistryProceedings of the National Academy of SciencesPeer-reviewed
Fructose-2,6-bisphosphate restores DNA repair activity of PNKP and ameliorates neurodegenerative symptoms in Huntingtons disease
Anirban Chakraborty, Sravan Gopalkrishnashetty Sreenivasmurthy, Wyatt Miller…·Tapas K. Hazra
This study shows that F2,6BP restores PNKP activity and alleviates neurodegenerative symptoms in HD and SCA3 by rescuing DNA repair and genome integrity.