Author

Lisardo Boscá

Consejo Superior de Investigaciones CientíficasORCID 0000-0002-0253-5469Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Organism:Drosophila· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

Anirban ChakrabortyiD· 2 shared Balaji KrishnaniD· 2 shared Gourisankar GhoshiD· 2 shared Santi M. MandaliD· 2 shared Sravan Gopalkrishnashetty SreenivasmurthyiD· 2 shared Tapan BiswasiD· 2 shared Tapas K. HazraiD· 2 shared Adrián Povo‐RetanaiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersNeuroscience

Anirban ChakrabortyORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

NeurosciencebioRxivPreprintMay 31, 2026

A Toxic Tau-PFKFB3 Circuit Reduces F2,6BP Levels and Drives Neurodegeneration

Santi M Mandal, Anirban Chakraborty, Shandy Shahabi…·Gourisankar Ghosh

This paper identifies the PFKFB3-F2,6BP metabolic axis as a key driver of Alzheimer's disease by linking metabolic dysregulation to genomic stability and Tau proteostasis, showing that F2,6BP supplementation rescues AD phenotypes across multiple models.

DOI 10.64898/2026.05.28.728580

humanDrosophila

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BiochemistryProceedings of the National Academy of SciencesPeer-reviewedSep 19, 2024

Fructose-2,6-bisphosphate restores DNA repair activity of PNKP and ameliorates neurodegenerative symptoms in Huntingtons disease

Anirban Chakraborty, Sravan Gopalkrishnashetty Sreenivasmurthy, Wyatt Miller…·Tapas K. Hazra

This study shows that F2,6BP restores PNKP activity and alleviates neurodegenerative symptoms in HD and SCA3 by rescuing DNA repair and genome integrity.

10 citations

humanmouse

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