Tapas K. Hazra

This paper identifies the PFKFB3-F2,6BP metabolic axis as a key driver of Alzheimer's disease by linking metabolic dysregulation to genomic stability and Tau proteostasis, showing that F2,6BP supplementation rescues AD phenotypes across multiple models.

This study shows that fructose-2,6-bisphosphate (F2,6BP) restores genome repair and motor function in TDP-43 pathology-driven motor neuron diseases.

This paper shows that F2,6BP restores mitochondrial genome integrity in Huntington's Disease by rescuing PNKP activity and mitochondrial function.

The paper shows that Huntingtin (HTT) helps maintain mitochondrial DNA integrity by organizing a repair complex, which is disrupted by mutant HTT in Huntington's disease, leading to DNA damage and motor deficits in a fly model.

This study shows that e-cigarette vaping increases adenoma formation in a mouse model of colorectal cancer, with dual exposure to e-cigarettes and cigarettes leading to greater tumorigenesis.

This study shows that F2,6BP restores PNKP activity and alleviates neurodegenerative symptoms in HD and SCA3 by rescuing DNA repair and genome integrity.