Author

Itzia Zaleta-Linares

University of California, San FranciscoORCID 0009-0001-1637-271XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Immunology· 2 Bioengineering· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Approach:experimental assay· 2 Organism:human· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Assay:CITE-seq· 1

Frequent Co-Authors

Alexis J. CombesiD· 3 shared Kenneth H. HuiD· 3 shared Matthew F. KrummeliD· 3 shared Tristan CourauiD· 3 shared Arja RayiD· 2 shared Brittany R. DavidsoniD· 2 shared Bushra SamadiD· 2 shared Nicholas F. KuhniD· 2 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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3 shared papersImmunology

Alexis J. CombesORCID

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3 papers

Recent·Most cited

BioengineeringThe Journal of Experimental MedicinePeer-reviewedMar 25, 2026

Discovery of a Linked Constellation of Gene Expression Revealed by Local Editing of Fibroblasts in Tumors

Nicholas F. Kuhn, Itzia Zaleta-Linares, Kenneth H. Hu…·Matthew F. Krummel

The paper uses local gene editing in mouse tumor models to discover a novel fibroblast state and its impact on the tumor microenvironment.

3 citations

mousegenetic perturbation / CRISPR

𝕏 PostBluesky

ImmunologyScience ImmunologyPeer-reviewedJul 11, 2025

Multimodal delineation of a layer of effector function among exhausted CD8 T cells in tumors

Arja Ray, Molly A. Bassette, Kenneth H. Hu…·Matthew F. Krummel

The paper identifies a potent effector state among exhausted CD8 T cells in tumors using multimodal CITE-Seq, showing enhanced cytokine production and tumor-killing ability.

10 citations

𝕏 PostBluesky

ImmunologyThe Journal of Experimental MedicinePeer-reviewedOct 31, 2024

Critical role of CD206+ macrophages in promoting a cDC1-NK-CD8 T cell anti-tumor immune axis

Arja Ray, Kenneth H. Hu, Kelly Kersten…·Matthew F. Krummel

This study shows that CD206+ macrophages support an anti-tumor network involving cDC1, NK cells, and CD8 T cells, and their depletion impairs tumor control in mice and correlates with poor survival in humans.

73 citationstop 1%

𝕏 PostBluesky