Simon Keely

This study identifies distinct duodenal microbiota and immune profiles in functional dyspepsia patients compared to controls, suggesting disrupted host-microbiome homeostasis.

The paper identifies a novel microbiota-derived protein, BMG-1, that inhibits neutrophil elastase and protects the intestinal barrier in IBD.

This study shows that GSDMD pore formation stops caspase-4 activity to control IL-18 production in intestinal epithelial cells, preventing excessive inflammation.

This study shows that antibiotic-induced microbiome modulation in mice alters immune responses to gluten, increasing duodenal eosinophils and activating epithelial γδ T-cells.

This study shows hypoxia reduces the effectiveness of hypomethylating agents in AML cells by altering DNA methylation and antigen presentation pathways.

This paper identifies microbiome-derived therapeutics for IBD using a metagenome-guided approach, showing improved disease markers and safety in preclinical models.

This study shows that fecal microbial transfer and complex carbohydrates can reduce COPD symptoms in mice and humans, linking gut microbiota to disease progression.