Elliott Somerville

This study tracks antisense oligonucleotides (ASOs) through endocytic trafficking, finding that productive escape occurs early in endosomes before sequestration in late compartments.

This study shows that tau seeding in neurons occurs via transient endolysosomal perforations that remain confined within endolysosomes and require PIKfyve activity.

The paper uses FIB-SEM and ASEM to identify and characterize vesicular ER exit sites in mammalian cells, revealing their abundance and organization.

This study identifies endomembrane depletion as a key factor in phagocytic capacity exhaustion in macrophages.

The paper shows that neurons have constitutive endolysosomal perforations enabling internalized alpha-synuclein fibrils to induce aggregation, and inhibiting PIKfyve kinase reduces this effect.