Sergey E. Dmitriev

The paper links epigenetic regulatory patterns across mammalian aging, development, and mortality using DNA methylation analysis in blood.

This paper investigates the role of the β-hairpin loop in the SUI1 domain of DENR/Tma22p in yeast, showing its critical function in ribosome recycling and reinitiation.

The paper identifies the p48 isoform of ITAF45 as essential for EMCV and Mengovirus replication, showing isoform-specific roles in IRES-driven translation.

This study shows that eIF4F and eIF4B enhance translation termination by promoting eRF1 loading and eRF3 GTPase activity in a closed-loop mRNA structure.

This study identifies transcriptomic biomarkers of mortality across species and models, revealing common aging mechanisms and rejuvenation signatures.

This study develops a trivalent mRNA vaccine candidate for seasonal flu, showing higher immunogenicity and cross-specific humoral immune response compared to an inactivated split vaccine.

This study evaluates mRNA-LNP vaccines encoding SARS-CoV-2 structural proteins, finding that the S protein enhances immune responses to N protein, while M protein has low immunogenicity.

This study introduces dicistrovirus IRESs into UAS/SV40-polyA constructs in Drosophila, leading to premature polyadenylation and enhanced overexpression of upstream ORFs.

The paper develops a fluorescent reporter system to monitor the integrated stress response in live Drosophila, revealing tissue-specific stress regulation during infections.

The paper analyzes transcriptomic and proteomic data to identify tissue-specific expression of translation machinery components and highlights sexual dimorphism in translation factors.

This paper develops an mRNA platform for delivering single-domain antibodies, achieving 100% protection against high doses of botulinum neurotoxin A in mice.

This study identifies a transcriptomic signature of reprogramming in mouse and human cells that reverses age-related gene expression changes and reveals mechanisms of rejuvenation independent of pluripotency gain.

The paper describes a method to enhance transgene expression in Drosophila melanogaster by preventing mRNA degradation through specific sequences.

The paper investigates how a standard knockout procedure in yeast affects the expression of neighboring genes at the translational level, revealing significant changes in protein abundance.

This study examines age-related changes in the transcriptome and translatome of mouse tissues, revealing U-shaped gene expression patterns and age-related declines in protein synthesis.

This study characterizes epigenetic aging in human classical monocytes, identifying age-associated DNA methylation changes and their links to gene expression and disease associations.