Michael Ehrmann

This study identifies TRIP12 as a proteostasis-responsive E3 ligase that regulates protein stability and the proteostasis network under proteotoxic stress.

This paper develops a mouse model of cardiac AL amyloidosis that reproduces human disease features, including amyloid deposits and cardiac dysfunction, and identifies a role for partial LC degradation in fibril formation.

This study identifies HTRA1 as a non-autonomous protein quality control factor that inhibits tau aggregate propagation by interfering with multiple steps of the spreading process.

The paper identifies rare variants in HTRA1 and its substrate EGFL8 associated with increased white matter hyperintensities using whole-exome sequencing data from 16,511 UK Biobank individuals.