Joris Messens

This study identifies PTPRF as a stress-responsive cytoskeletal checkpoint that coordinates metabolic adaptation in hepatocytes and β cells by linking metabolic stress to actin reorganization.

This study shows disease-linked mutations in hnRNPA2B1 accelerate condensate maturation and promote amyloid aggregation by altering phase separation and fibril formation.

This study attempts to reconstitute the transient Prdx2:STAT3 redox-relay complex in vitro but finds it challenging due to its redox-dependent nature and susceptibility to hyperoxidation.

This paper shows that pervanadate induces oxidation, which activates SRC kinases by disrupting autoinhibition and altering SH2 domain phosphopeptide binding, revealing a redox-dependent mechanism for SRC activation.

The paper shows that eukaryotic Prx1/AhpC-type peroxiredoxins form heterooligomers, which modulate their structure and stability, challenging the previous belief in homooligomerization.

This study identifies 225 redox-active nuclear proteins in Arabidopsis, including GCN5, modified by sulfenylation under oxidative stress, revealing their functional impact on protein interactions.

The paper introduces NAPstar biosensors to measure NADP redox states and finds glutathione mediates anti-oxidative electron flux across eukaryotes.

This study identifies PTPRK's role in promoting hepatocyte metabolic reprogramming in obesity by regulating glycolysis and lipogenesis, with potential therapeutic implications for obesity-related liver diseases.

This study uses Thermal Proteome Profiling to identify proteomic responses to localized H2O2 production in different cellular compartments.

The paper uses AlphaFold2 predicted structures to analyze cysteine disulfides and metal binding sites in plant proteomes, finding high agreement with experimental structures and evolutionary trends in metal binding.