J. Messens

The NAPstar family of NADP redox state sensors highlights glutathione as the primary mediator of anti-oxidative electron flux

The paper introduces NAPstar biosensors to measure NADP redox states and finds glutathione mediates anti-oxidative electron flux across eukaryotes.

Protein tyrosine phosphatase receptor kappa regulates glycolysis and de novo lipogenesis to promote hepatocyte metabolic reprogramming in obesity

This study identifies PTPRK's role in promoting hepatocyte metabolic reprogramming in obesity by regulating glycolysis and lipogenesis, with potential therapeutic implications for obesity-related liver diseases.

Monitoring oxidative inflammatory processes in live cells and tissue with Hypocrates, a genetically encoded biosensor for hypochlorite

Charge Interactions in a Highly Charge-depleted Protein

This study investigates charge interactions in a charge-depleted protein using simulations and experiments, revealing context-dependent residue interactions and their impact on protein stability.

Identification of sulfenylated cysteines in Arabidopsis thaliana proteins using a disulfide-linked peptide reporter

This study identifies sulfenylated cysteines in Arabidopsis thaliana using a transgenic Yap1 probe, revealing over 1,000 proteins with sulfenylated residues.

Redox response of iron-sulfur glutaredoxin GRXS17 activates its holdase activity to protect plants from heat stress

This study identifies GRXS17 as a redox-regulated holdase that protects plants from heat stress by shifting its activity through Fe-S cluster oxidation.