Daria Ezeriņa

This study identifies PTPRF as a stress-responsive cytoskeletal checkpoint that coordinates metabolic adaptation in hepatocytes and β cells by linking metabolic stress to actin reorganization.

This study attempts to reconstitute the transient Prdx2:STAT3 redox-relay complex in vitro but finds it challenging due to its redox-dependent nature and susceptibility to hyperoxidation.

This paper shows that pervanadate induces oxidation, which activates SRC kinases by disrupting autoinhibition and altering SH2 domain phosphopeptide binding, revealing a redox-dependent mechanism for SRC activation.

This study identifies PTPRK's role in promoting hepatocyte metabolic reprogramming in obesity by regulating glycolysis and lipogenesis, with potential therapeutic implications for obesity-related liver diseases.

This study uses Thermal Proteome Profiling to identify proteomic responses to localized H2O2 production in different cellular compartments.