Borries Demeler

This study identifies how SpNanR activates sialic acid metabolism in S. pneumoniae by binding N-acetylmannosamine-6-phosphate, stabilizing its tetramer and enhancing transcription of the nan and siaA operons.

This study identifies donor strand complementation and calcium ion coordination as key drivers of chaperone-free cannulae polymerization in archaea.

The paper investigates how a disordered linker in the Polyhomeotic protein influences phase separation and oligomerization in Drosophila and human cells through in vitro reconstitution and molecular dynamics simulations.

This paper shows that cationic liposome-formulated TLR7/8 agonist enhances fentanyl vaccine efficacy by improving immune activation and protecting against fentanyl-induced toxicity in rats.

This study investigates how BMP-9 and BMP-10 form disulfide bonds and dimers, showing that geometric strain, not cysteinylation, reduces dimerization propensity and that residue swaps can reverse this effect.

This study investigates the structural plasticity of calpain-3, showing it forms a hexamer that dissociates into dimers upon binding titin.

This paper investigates the binding specificity of CECR2-BRD to acetylated histone and non-histone ligands, revealing distinct binding modes and functional roles in chromatin regulation and inflammation.

This study elucidates how NanR represses sialic acid metabolism in E. coli by showing its cooperative DNA binding and allosteric regulation by N-acetylneuraminate.