Thomas Alexander Quinn

This study compares the defibrillation efficacy of different channelrhodopsins in human cardiac tissue using simulations, finding that ion selectivity affects arrhythmia termination mechanisms and success.

This study shows that disturbed repolarisation-relaxation coupling during acute ischaemia increases systolic mechano-arrhythmogenesis, which can be mitigated by restoring coupling or targeting calcium, TRPA1, or ROS.

This study shows that TRPA1 activation and disrupted repolarisation-relaxation coupling during systole contribute to mechano-arrhythmogenesis in ischaemic conditions.

This study identifies perivascular excitation tunnelling (PVET) as a novel mechanism causing reperfusion arrhythmias and shows that two-step reperfusion can prevent it in rabbit and pig hearts.

The paper profiles the transcriptome of the zebrafish atrioventricular canal to identify molecular signatures of pacemaker and valve mesenchyme, revealing conserved features with mammalian AV node and cardiac valves.