Peter Karl Kohl

This study compares the defibrillation efficacy of different channelrhodopsins in human cardiac tissue using simulations, finding that ion selectivity affects arrhythmia termination mechanisms and success.

The paper quantifies TATS ultrastructural features across eight mammalian species and finds correlations between TATS density, cardiomyocyte size, and physiological parameters like heart rate and lifespan.

This study shows that disturbed repolarisation-relaxation coupling during acute ischaemia increases systolic mechano-arrhythmogenesis, which can be mitigated by restoring coupling or targeting calcium, TRPA1, or ROS.

This study uses single-cell RNA-sequencing and spatial transcriptomics to analyze the spatio-temporal dynamics of the fibrotic niche in cardiac repair after ventricular injury in adult mice, identifying key cell interactions and regulatory mechanisms.

This study compares stretch-activated channel activity in bone marrow-derived and cardiac tissue-resident macrophages, finding that Piezo1 activity is absent in the latter.

This study shows that TRPA1 activation and disrupted repolarisation-relaxation coupling during systole contribute to mechano-arrhythmogenesis in ischaemic conditions.

The paper demonstrates that cardiac myocyte T-tubules can generate action potentials autonomously, distinct from those in the sarcolemma, using an all-optical method.

This study examines age-related changes in cardiac Schwann cells, parasympathetic nerve fibers, and M2R expression in mice, finding reduced SC density, fewer parasympathetic fibers, and lower M2R expression in aged hearts, which correlates with increased arrhythmia risk.

The paper quantifies the 3D structure and distribution of fibroblasts and macrophages in healthy and cryo-ablated mouse hearts using fluorescent labeling and imaging.

This study identifies perivascular excitation tunnelling (PVET) as a novel mechanism causing reperfusion arrhythmias and shows that two-step reperfusion can prevent it in rabbit and pig hearts.

This study examines the structure and dynamics of cardiac fibroblast nanotubes in human atrial tissue and cell lines, showing their role in intercellular communication and ECM interaction.

The paper profiles the transcriptome of the zebrafish atrioventricular canal to identify molecular signatures of pacemaker and valve mesenchyme, revealing conserved features with mammalian AV node and cardiac valves.

This study identifies two stretch-activated ion channels, Piezo1 and BKCa, in human atrial fibroblasts and shows their differential regulation in atrial fibrillation.