Myra D.T. Hosmillo

This paper identifies cereblon (CRBN) as a host factor that promotes influenza virus replication by degrading AMPK, shifting cellular metabolism to support viral growth.

This study develops an ex vivo model to investigate zoonotic transmission of noroviruses, showing human norovirus can bind and replicate in pig tissue but not chicken tissue.

The paper develops ARTIC HELP, an open-source alternative to ARTIC nanopore sequencing protocols using commercial enzymes, achieving comparable genome coverage for SARS-CoV-2 and Norovirus GII with reduced supply chain dependencies.

This study analyzes within-host SARS-CoV-2 evolution in chronic infections, finding variable rates of evolution and evidence of subpopulation structure.

This study shows that the porcine sapovirus protease NS6 inhibits type I IFN production by targeting TBK1, revealing a mechanism for immune evasion and establishing a new cell line model for PSaV research.

This study shows that the cGAS-STING pathway restricts noroviruses by detecting leaked genomic and mitochondrial DNA, leading to IFN responses.

The paper identifies potent siRNAs against SARS-CoV-2 through RNAi screening, validates their efficacy against variants, and demonstrates their prophylactic potential in a hamster model.