Hong‐Gang Wang

This study evaluates the anti-leukemic effects of LCL-805, an acid ceramidase inhibitor, in AML cell lines and patient samples, showing it promotes iron-dependent cell death by antagonizing Akt signaling.

This study develops optical imaging methods to analyze subcellular localization and dynamics of voltage-gated sodium channels in neurons, revealing developmental regulation and a novel trafficking pathway.

This study identifies genetic regulators of PARP inhibitor response using CRISPR screens, revealing TIP60 as a key factor that reverses PARPi sensitivity in BRCA2-deficient cells.