Christopher S. Ashe

The paper compares single-cell transcriptomes of mouse and human tubal epithelium to show injury-driven regeneration in humans may contribute to ovarian cancer initiation.

This study identifies 44 genes, including novel markers like OAS2 and OASL, as potential early diagnostic and prognostic markers for serous endometrial carcinoma using a mouse model and multi-omics approaches.

This study uses combinatorial CRISPR mutagenesis in organoids to identify gene combinations driving malignant transformation, pathology, and chemosensitivity in high-grade serous ovarian carcinoma.

The paper identifies pre-ciliated tubal epithelial cells as a cancer-prone state in high-grade serous ovarian carcinoma by analyzing mouse uterine tube cell states and lineage dynamics.