Author

Daryl J. Phuong

Cornell UniversityORCID 0000-0003-4049-8694Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 3 Cell Biology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 4 Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Approach:genetic perturbation / CRISPR· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

Alexander Yu. NikitiniD· 3 shared Andrea Flesken‐NikitiniD· 3 shared Coulter Q. RalstoniD· 3 shared John C. SchimentiiD· 3 shared Amanda P. ArmstrongiD· 2 shared Benjamin D. CosgroveiD· 2 shared Christopher S. AsheiD· 2 shared Andrea Joseph De MicheliiD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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3 shared papersCancer Biology

Alexander Yu. NikitinORCID

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4 papers

Recent·Most cited

Cancer BiologybioRxivPreprintSep 20, 2026

Cross-species analysis links cell-cell communication rewiring to NOTCH2 during serous endometrial carcinogenesis

Matalin G. Pirtz, Andrea Flesken‐Nikitin, Coulter Q. Ralston…·Alexander Yu. Nikitin

DOI 10.64898/2026.09.01.748540

𝕏 PostBluesky

Cell BiologybioRxivPreprintMay 16, 2025

Embryonic Stem Cell-Specific Responses to DNA Replication Stress

Ryan C. James, Jerry K. Wang, Siddhanth R. Bhatt…·John C. Schimenti

This study investigates how mouse embryonic stem cells respond to DNA replication stress, finding they survive via ATR- and CHK1-dependent mechanisms but lack a strong G2/M checkpoint and repair DNA crosslinks in S phase.

DOI 10.1101/2025.05.16.654332

mouseDNA methylation

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Cancer BiologybioRxivPreprintMar 10, 2025

Combinatorial organoid mutagenesis screen reveals gene constellations driving malignant transformation, pathology and chemosensitivity in high-grade serous ovarian carcinoma

Daryl J. Phuong, Coulter Q. Ralston, Tamer Ezzat…·John C. Schimenti

This study uses combinatorial CRISPR mutagenesis in organoids to identify gene combinations driving malignant transformation, pathology, and chemosensitivity in high-grade serous ovarian carcinoma.

1 citation

mouseorganoid / primary culture

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Cancer BiologyNature CommunicationsPeer-reviewedOct 4, 2024

Pre-ciliated tubal epithelial cells are prone to initiation of high-grade serous ovarian carcinoma

Andrea Flesken‐Nikitin, Coulter Q. Ralston, Dah‐Jiun Fu…·Alexander Yu. Nikitin

The paper identifies pre-ciliated tubal epithelial cells as a cancer-prone state in high-grade serous ovarian carcinoma by analyzing mouse uterine tube cell states and lineage dynamics.

25 citationstop 4%

mousebulk RNA-seq

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