Meindert Hugo Lamers

The paper presents the cryo-EM structure of MutL-bound MutH on a hemi-methylated GATC site, revealing the mechanism of MutH activation for strand discrimination.

The paper identifies amino acid changes in M. smegmatis DnaE1 that affect DNA polymerase fidelity through in silico and experimental approaches.

PyVADesign is a Python tool that streamlines the design and ordering of dsDNA fragments for generating large mutant libraries, with automated primer design.

This study investigates how DNA polymerase displaces SSBs during replication, showing sequential displacement and the role of SSB saturation in replication efficiency.

This study identifies NAD-dependent dehydrogenases in Paracoccus denitrificans that enable efficient bacterial growth on ethylene glycol, with implications for biotechnological applications.

This study determines the cryo-EM structure of the MmpS5L5 efflux pump in Mycobacterium tuberculosis and identifies mutations that enhance bedaquiline efflux, suggesting new resistance mechanisms.

The paper shows that mutations in SsgB, a protein that recruits FtsZ, cause longitudinal cell division in Streptomyces by altering septum placement.