Author

Laurent Provins

UCB Pharma (Belgium)ORCID 0000-0002-4352-7086Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:cryo-EM· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1 Research Focus:protein structure prediction· 1 Research Focus:synaptic & neural circuits· 1

Frequent Co-Authors

Adrian HalliD· 2 shared Anshumali MittaliD· 2 shared Christian WolffiD· 2 shared Jonathan A. ColemaniD· 2 shared Matthew F. MartiniD· 2 shared Michel R. GillardiD· 2 shared Peter S. HoranyiiD· 2 shared David L. SulzeriD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersBiochemistry

Adrian HallORCID

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2 papers

Recent·Most cited

BiochemistrybioRxivPreprintSep 13, 2026

Structural Determinants of Synaptic Vesicle Protein 2C Ligand Selectivity and Their Impact on Dopamine Release

Matthew F. Martin, Meghan L. Bucher, Se Joon Choi…·Jonathan A. Coleman

This study presents cryo-EM structures of SV2C and its ligands, revealing structural differences that explain ligand selectivity and impact dopamine release.

DOI 10.64898/2026.09.10.750697

mousecryo-EM

𝕏 PostBluesky

BiochemistryProceedings of the National Academy of SciencesPeer-reviewedSep 2, 2025

Mechanisms Underlying Allosteric Modulation of Antiseizure Medication Binding to Synaptic Vesicle Protein 2A (SV2A)

Anshumali Mittal, Matthew F. Martin, Laurent Provins…·Jonathan A. Coleman

This paper reveals how UCB1244283 enhances BRV and LEV binding to SV2A by occupying an allosteric site, explaining its selectivity and potential for targeted therapeutics.

7 citations

experimental assayhost-pathogen & immune response

𝕏 PostBluesky