James Richard Whittle

SpaMTP integrates spatial metabolomics and transcriptomics data through a comprehensive analysis pipeline and visualization tools.

This paper introduces a workflow for integrating spatial transcriptomics and metabolomics data to analyze glioma tissue, identifying novel biological features at the tumor's infiltrating edge.

This paper compares patient-derived neurosphere and organoid models of glioblastoma, showing they retain intra-tumoral heterogeneity and respond to chemotherapy.

TIRE-seq streamlines RNA-seq workflows by integrating mRNA purification into library preparation, improving efficiency and data quality in perturbation studies.

This study shows that spermidine, a metabolite from glioblastoma cells, suppresses CD8+ T cell function, promoting tumor growth and poor patient outcomes.

This study evaluates sample multiplexing reagents and protocols for scRNA-Seq, finding that workflow improvements and reagent choice impact data quality and cost-effectiveness.

The paper compares matrix, deposition technique, and polarity settings in MALDI-TOF mass spectrometry imaging for brain tumors, finding recrystallized cyano-4-hydroxycinnamic acid in positive polarity provides best performance.