Jan Philipp Kreysing

The paper reports an extended structure of the human nuclear pore complex, revealing TREX-2 components as integral parts of the nuclear ring.

This study uses in situ structural biology to reveal the molecular organization of chromatin at the nuclear periphery in human cells.

This study uses cryo-electron tomography to show vault particles associate with ER and nuclear envelope membranes and enclose ribosomes in Dictyostelium discoideum.

cryoTIGER uses deep learning to generate intermediate tilt images in cryo-electron tomography, improving 3D reconstruction and structural recovery.

This study shows that nuclear pore complexes dilate during cell differentiation and that Nup133 deficiency prevents this dilation, leading to nuclear envelope instability.

This study investigates how HIV-1 capsids pass through nuclear pores, finding that capsids retain their structure and cause NPC scaffold rings to crack.

This study shows that Dictyostelium discoideum uses nuclear pores as conduits for fluid flow during osmotic stress, distinct from passive diffusion and active transport.

This paper introduces a high-confidence 3D template matching method for CryoET, enabling accurate localization of cellular structures with improved statistical confidence.