Leonard D. Shultz

This study introduces a novel humanized FLT3 mouse model that supports enhanced development of human innate immune cells and HIV-1 persistence, mimicking human viral reservoirs.

The paper maps the morphological and functional maturation of human endocrine pancreas from birth to age 10 using pediatric tissue samples and imaging techniques.

This study identifies redundant γc cytokines that enhance IL-1-driven neutrophil inflammation via MEK/ERK convergence, showing that blocking the shared γc receptor or MEK/ERK reduces disease severity.

This study shows that blocking glucagon signaling increases non-alpha cell proliferation in islets, dependent on SLC7A2 and mTORC1, across multiple species and models.

This study shows human T-cell development in humanized mice can occur without mouse MHCs and is enhanced by lentiviral delivery of HLA and cytokines.

The paper establishes NSG+hIL6 mice as a model for studying multiple myeloma by showing they support engraftment of patient-derived myeloma cells and develop disease features.

This study develops a humanized mouse model to investigate the role of innate immunity in FSHD muscle pathology and identifies immune cell accumulation and complement gene expression in FSHD muscle xenografts.

The paper shows that gene disruption strategies in mice can lead to unexpected exon skipping and translation, resulting in gain-of-function alleles instead of null phenotypes.

The paper develops a method to efficiently edit LT-HSCs at single-cell resolution and demonstrates distinct functional outcomes of GATA1 editing.

The paper shows ADAM17 is the main enzyme that removes the outer part of the AREG protein, which is important for skin health and cancer.