Johanna K. Freundt

This study examines how mavacamten affects skeletal muscle structure by reducing ON-state myosin heads and shortening thin filament length, similar to its effects in cardiac muscle.

This study shows that titin cleavage in mice causes concentric cardiac remodeling, diastolic dysfunction, and fibrosis by disrupting mechanical connectivity.

The paper investigates how titin-based forces affect cardiac myofilament structures under stretch, supporting the Frank-Starling mechanism.