Patrick Lagüe

The paper uses deep mutational scanning to analyze resistance mutations in Fks1, revealing distinct resistance landscapes for echinocandins and triterpenoids, including a novel triterpenoid-specific hotspot.

The paper identifies that peptide hydrophobicity affects their availability in yeast cells, impacting synthetic interaction strength beyond in vitro measurements.

The paper quantifies amino acid side-chain insertion energetics in a POPC bilayer using unbiased molecular dynamics simulations and derives potentials of mean force to characterize bilayer partitioning.

The paper identifies key residues in Fks hotspots that confer echinocandin resistance in Saccharomyces cerevisiae using molecular dynamics and deep-mutational scanning.

This study identifies LaTMT2 as a Golgi-localized N-methyltransferase that resolves competing models of galanthamine biosynthesis and provides a target for metabolic engineering.

This study demonstrates that SaCas9-mediated deletion restores dystrophin expression in DMD patient-derived myoblasts and in vivo in a mouse model.