Alexander R. Dunn

The paper identifies nanoscale clustering of Latrophilin-3 as a mechanism driving excitatory synapse assembly, showing that clustering, not ligand binding, is critical for synapse formation.

The paper investigates how cluster assembly dynamics contribute to planar cell polarity polarization by analyzing protein monomer counts in live animals and using mathematical modeling.

The paper introduces IDiom, a language model for generating intrinsically disordered protein sequences, showing it can produce sequences with biologically relevant features and subcellular localization properties.

This study introduces SM3FS, a high-throughput microfluidic force spectroscopy method to analyze DNA mechanosensitivity, identifying structures that are kinetically stable but mechanically fragile.

This study uses cryo-ET to show that MYH7 P710R mutations disrupt thick filament organization in HCM cardiomyocytes, leading to sarcomeric disarray and ribosome infiltration.

This study shows that loss of ROR2 leads to endothelial dysfunction in PAH through inappropriate integrin beta 1 activation, impairing barrier integrity and angiogenesis.

This study uses cryo-ET to analyze the structure of thin filaments in human iPSC-derived cardiomyocytes and how they change with disease-related perturbations.

This study shows that PDZ domains from afadin and ZO-1 act as mechanosensors, forming catch bonds or weakening under mechanical force, affecting cell-cell adhesion stability.

The paper investigates chromatin accessibility changes in neurogenic niche cells during aging, identifying defects in NSC adhesion and migration and proposing ROCK inhibition as a potential therapeutic strategy.

This study identifies actin polymerization as the mechanism driving lumen formation in human epiblast models, showing it initiates lumen opening and transitions to pressure-driven growth as the lumen expands.

This paper introduces a novel CAR T cell platform using proximal T cell signaling molecules to enable Boolean logic-gated control, improving efficacy and reducing off-tumor toxicity.

The paper shows that oscillatory cortical forces drive 3D cell intercalations in the mouse mandibular arch, shaping embryonic structures through Wnt5a, YAP/TAZ, and PIEZO1.