Thomas Graham Bird

This study shows that p53 and cholesterol drive liver fibrosis and systemic fibrosis in MASH, with sex-specific effects in mice.

This study evaluates Tegavivint's efficacy and safety in Wnt-activated HCC, showing potent anti-tumour activity and safety in preclinical models.

The paper quantifies signalling effects of CTNNB1 mutations across cancer types and finds weakly activating mutations correlate with worse prognosis in hepatocellular carcinoma.

The paper identifies L-pentahomoserine as a bacterial metabolite linked to better survival in esophageal cancer by supporting metabolic adaptations under nutrient stress.

PixlMap is a deep learning method for cellular phenotyping in multiplex immunofluorescence images that uses nuclear segmentation alone to classify cells without requiring full cell boundaries.

The paper shows that eIF4A2, a negative regulator of mRNA translation, promotes ECM deposition to accelerate HCC initiation by influencing integrin-mediated signaling and senescence exit.

The paper identifies Notch signalling as essential for secondary senescence, distinguishing it from primary senescence through molecular endpoints.