Rohan Varshney

This study shows that diet-induced changes in phospholipid composition affect ferroptosis sensitivity and tumorigenesis in pancreatic cancer.

This study shows that large adipocytes release lipids via extracellular vesicles, promoting breast cancer cell migration and proliferation, and links this to human dyslipidemia and triglyceride levels.

This study shows Disulfiram protects against obesity and insulin resistance through GSDMD-independent mechanisms by reprogramming systemic lipid handling.

This study shows that the Wnt/lipogenesis axis mediates lipodystrophy and recovery in skin fibrosis by regulating lipid content and extracellular matrix.

This study shows that maternal exercise during lactation improves milk fatty acid composition and enhances offspring energy expenditure in obese dams.

This study shows that early-life exposure to high omega-6 fatty acids impairs adipocyte mitochondrial oxidation by suppressing NR2F2, which can be reversed by reactivating NR2F2 in stem-like cells.

This study identifies lipid metabolic reprogramming in endocrine-resistant breast cancer cells, showing TVB-2640 reduces lipid storage but not cell growth.

This study investigates MLKL's non-necroptotic roles in diet-induced obesity and liver disease using a HFHFrHC mouse model, finding dose-dependent effects on inflammation and metabolic parameters.

This paper shows that PROX1 inhibits PDGF-B expression in heart valves to prevent myxomatous degeneration, and PDGF-B inhibition ameliorates valve defects in mice.

This study shows that deleting melanocortin-4 receptors on hypothalamic astrocytes increases body weight, feeding, and central inflammation, independent of neuronal MC4R effects.